Wavefront sensors are simple and robust phase sensors at the basis of adaptive optics in astronomy and bio-imaging. Adaptive optics has been introduced in bio-imaging to compensate smooth aberrations mostly arising from the refractive index mismatch a ...
A simple, inexpensive and multi-scale 3-D fluorescent test sample for optical sectioning microscopies
Pyranine-labeled tissue paper, imaged upon 405-nm epifluorescence excitation through a 455LP LP dichroic and 465LP emission filter. Objective ×20/NA0.25. Overlaid are the normalised absorbance (dashed) and emission spectra (through line), respectively. I ...
Unraveling how neural networks process and represent sensory information and how these cellular signals instruct behavioral output is a main goal in neuroscience. Two-photon activation of optogenetic actuators and calcium (Ca 2+) imaging with gen ...
Artist illustration of chromatic speckle expansion after a scattering sample. (© Clément Molinier) Imaging deep in scattering tissues has been typically achieved by exciting non-linear optical processes thanks to broadband ultrashort laser pulses. Scatte ...
Read it here : Supercritical angle microscopy and spectroscopy Authors: Martin Oheim, Adi Salomon, Maia Brunstein Abstract: Fluorescence detection, either involving propagating or near-field emission, is widely being used in spectroscopy, sensing and micro ...
Total internal reflection sets up an evanescent wave that – when used for microscopic imaging – renders the microscope short-sighted and enables the selective observation of the near-membrane space. But how deep is deep? In this Biophysical Pe ...
Fast volumetric Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope
Imaging large tissue volumes at high spatio-temporel resolution has been a major challenge for scanning-type 2-photon microscopes. Now, SPPIN researchers around Martin Oheim and from TILL.id (Munich) designed and successfully validated a new microscope sch ...
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