We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.

Recent Publications

Articles

• Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
  Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020
• Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn.
  Houdou M, Lebredonchel E, Garat A, Duvet S, Legrand D, Decool V, Klein A, Ouzzine M, Gasnier B, Potelle S, Foulquier F : FASEB J, 2019
• Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E.
  Liang C, Carrel D, Omelchenko A, Kim H, Patel A, Fanget I, Firestein BL : Cereb Cortex, 2018
• Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
  Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLOS ONE, 2017
• Meeting after meeting: 20 years of discoveries by the members of the Exocytosis-Endocytosis Club.
  Niedergang F, Gasman S, Vitale N, Desnos C, Lamaze C : Biol Cell, 2017
• Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
  Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLoS One, 2017
• Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
  Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017
• SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
  Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017
• Superresolving dendritic spine morphology with STED microscopy under holographic photostimulation.
  Lauterbach MA, Guillon M, Desnos C, Khamsing D, Jaffal Z, Darchen F, Emiliani V : Neurophotonics, 2016
• Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter.
  Gasnier B : Biophys J, 2016
• Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
  Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM : Mol Biol Cell, 2015
• TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
  Cang C, Aranda K, Seo YJ, Gasnier B, Ren D : Cell, 2015