We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.

Former members

Recent Publications

Articles

• Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration.
  Liang C, Carrel D, Singh NK, Hiester LL, Fanget I, Kim H, Firestein BL : ASN Neuro, 2022
• Metabotropic glutamate receptor orthosteric ligands and their binding sites.
  Acher FC, Cabayé A, Eshak F, Goupil-Lamy A, Pin JP : Neuropharmacology, 2022
• Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
  Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021
• Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
  Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021
• A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers.
  Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP : Proc Natl Acad Sci U S A, 2021
• LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats.
  De Sa Nogueira D, Bourdy R, Filliol D, Quessada C, McCort-Tranchepain I, Acher F, Zwiller J, Romieu P, Befort K : Neurosci Lett, 2021
• Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
  Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021
• A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.
  Khamsing D, Lebrun S, Fanget I, Larochette N, Tourain C, de Sars V, Brunstein M, Oheim M, Carrel D, Darchen F, Desnos C : Mol Brain, 2021
• Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
  Gasnier B : Proc Natl Acad Sci U S A, 2021
• Free sialic acid storage disorder: Progress and promise.
  Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021
• Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.
  Orrico-Sanchez A, Chausset-Boissarie L, Alves de Sousa R, Coutens B, Rezai Amin S, Vialou V, Louis F, Hessani A, Dansette PM, Zornoza T, Gruszczynski C, Giros B, Guiard BP, Acher F, Pietrancosta N, Gautron S : Mol Psychiatry, 2020
• Illuminating the allosteric modulation of the calcium-sensing receptor.
  Liu H, Yi P, Zhao W, Wu Y, Acher F, Pin JP, Liu J, Rondard P : Proc Natl Acad Sci U S A, 2020
• LSP5-2157 a new inhibitor of vesicular glutamate transporters.
  Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N : Neuropharmacology, 2020
• Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism.
  Mikou A, Cabayé A, Goupil A, Bertrand HO, Mothet JP, Acher FC : Sci Rep, 2020
• Transporters in acidic organelles.
  Moriyama Y, Gasnier B : Biochim Biophys Acta Biomembr, 2020
• Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
  Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020
• Conformational pathway provides unique sensitivity to a synaptic mGluR.
  Habrian CH, Levitz J, Vyklicky V, Fu Z, Hoagland A, McCort-Tranchepain I, Acher F, Isacoff EY : Nat Commun, 2019
• Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23.
  Kansara M, Thomson K, Pang P, Dutour A, Mirabello L, Acher F, Pin JP, Demicco EG, Yan J, Teng MWL, Smyth MJ, Thomas DM : Cancer Discov, 2019
• The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures.
  Girard B, Tuduri P, Moreno MP, Sakkaki S, Barboux C, Bouschet T, Varrault A, Vitre J, McCort-Tranchepain I, Dairou J, Acher F, Fagni L, Marchi N, Perroy J, Bertaso F : Neurobiol Dis, 2019
• Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn.
  Houdou M, Lebredonchel E, Garat A, Duvet S, Legrand D, Decool V, Klein A, Ouzzine M, Gasnier B, Potelle S, Foulquier F : FASEB J, 2019
• Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.
  Tora AS, Rovira X, Cao AM, Cabayé A, Olofsson L, Malhaire F, Scholler P, Baik H, Van Eeckhaut A, Smolders I, Rondard P, Margeat E, Acher F, Pin JP, Goudet C : Neuropharmacology, 2018
• Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite assays.
  Belhocine A, Veglianese P, Hounsou C, Dupuis E, Acher F, Durroux T, Goudet C, Pin JP : Neuropharmacology, 2018
• Mutual activation of glutamatergic mGlu and muscarinic M receptors reverses schizophrenia-related changes in rodents.
  Cieślik P, Woźniak M, Rook JM, Tantawy MN, Conn PJ, Acher F, Tokarski K, Kusek M, Pilc A, Wierońska JM : Psychopharmacology (Berl), 2018
• Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.
  Zussy C, Gómez-Santacana X, Rovira X, De Bundel D, Ferrazzo S, Bosch D, Asede D, Malhaire F, Acher F, Giraldo J, Valjent E, Ehrlich I, Ferraguti F, Pin JP, Llebaria A, Goudet C : Mol Psychiatry, 2018
• Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.
  Selvam C, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AS, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, Leroux FR, Colobert F, Daniel H, Goupil-Lamy A, Bertrand HO, Goudet C, Pin JP, Acher FC : J Med Chem, 2018
• Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat.
  Lebourgeois S, Vilpoux C, Jeanblanc J, Acher F, Marie N, Noble F, Naassila M : Neuropharmacology, 2018
• Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist.
  Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N : Neuropharmacology, 2018
• Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E.
  Liang C, Carrel D, Omelchenko A, Kim H, Patel A, Fanget I, Firestein BL : Cereb Cortex, 2018
• Neurochemical and behavioral studies on the 5-HT-dependent antipsychotic action of the mGlu receptor agonist LSP4-2022.
  Woźniak M, Gołembiowska K, Noworyta-Sokołowska K, Acher F, Cieślik P, Kusek M, Tokarski K, Pilc A, Wierońska JM : Neuropharmacology, 2017
• Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
  Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S : Front Cell Neurosci, 2017
• Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
  Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLOS ONE, 2017
• Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
  Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017
• SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
  Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017

Book

• Ion and Molecule Transport in Lysosomes
  Bruno Gasnier, Michael X Zhu : CRC Press, Taylor & Francis Group, ISBN:9781138560390, (239 pages), 2020

Chapters

• Functional Study of Lysosomal Nutrient Transporters
  Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021
• Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands
  Goudet C, Rovira X, Rondard P, Pin J-P, Llebaria A, Acher F : extracted from Structure and Function of GPCRs Guillaume Lebon - Springer, pages 253-284, ISBN:978-3-030-24589-4, 2019