We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.

Former members

Recent Publications

Articles

• Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
  Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021
• A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.
  Khamsing D, Lebrun S, Fanget I, Larochette N, Tourain C, de Sars V, Brunstein M, Oheim M, Carrel D, Darchen F, Desnos C : Mol Brain, 2021
• Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
  Gasnier B : Proc Natl Acad Sci U S A, 2021
• Free sialic acid storage disorder: Progress and promise.
  Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021
• Transporters in acidic organelles.
  Moriyama Y, Gasnier B : Biochim Biophys Acta Biomembr, 2020
• Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
  Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020
• Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn.
  Houdou M, Lebredonchel E, Garat A, Duvet S, Legrand D, Decool V, Klein A, Ouzzine M, Gasnier B, Potelle S, Foulquier F : FASEB J, 2019
• Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E.
  Liang C, Carrel D, Omelchenko A, Kim H, Patel A, Fanget I, Firestein BL : Cereb Cortex, 2018
• Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.
  Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S : Front Cell Neurosci, 2017
• Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
  Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLOS ONE, 2017
• Meeting after meeting: 20 years of discoveries by the members of the Exocytosis-Endocytosis Club.
  Niedergang F, Gasman S, Vitale N, Desnos C, Lamaze C : Biol Cell, 2017
• Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
  Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLoS One, 2017
• Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
  Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017
• SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
  Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017
• Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors.
  Bouvier G, Higgins D, Spolidoro M, Carrel D, Mathieu B, Léna C, Dieudonné S, Barbour B, Brunel N, Casado M : Cell Rep, 2016
• Superresolving dendritic spine morphology with STED microscopy under holographic photostimulation.
  Lauterbach MA, Guillon M, Desnos C, Khamsing D, Jaffal Z, Darchen F, Emiliani V : Neurophotonics, 2016
• Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter.
  Gasnier B : Biophys J, 2016

Book

• Ion and Molecule Transport in Lysosomes
  Bruno Gasnier, Michael X Zhu : CRC Press, Taylor & Francis Group, ISBN:9781138560390, (239 pages), 2020

Chapter

• Functional Study of Lysosomal Nutrient Transporters
  Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021