Team 4 – Membrane dynamics
We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.
Team leader
Bruno Gasnier, Senior Research Scientist, PI, CNRS, Team 4 - Membrane dynamicsbruno.gasnier@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 15, room 626
Members
Christine Anne-Longin, Research Scientist, INSERM, Team 4 - Membrane dynamicschristine.anne@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 28, room 616
Damien Carrel, Assistant Professor, University of Paris, Team 4 - Membrane dynamicsdamien.carrel@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 12, room 626
Claire Desnos, Research Scientist, CNRS, Team 4 - Membrane dynamicsclaire.desnos@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 19, room 626
Isabelle Fanget, Engineer, CNRS, Team 4 - Membrane dynamicsisabelle.fanget@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 18, room 626
Océane Guelle, PhD Student, Team 4 - Membrane dynamicsoceane.guelle@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 29, room 616
Cécile Jouffret, Assistant engineer, CNRS, Team 4 - Membrane dynamicscecile.jouffret@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616
Solène Lebrun, Assistant engineer, CNRS, Team 4 - Membrane dynamicssolene.lebrun@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 23, room 626
Hynda Mimouni, Technician, University of Paris, Team 4 - Membrane dynamicshynda.mimouni@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616- Elodie Phommabouth, Technician, University of Paris, Team 4 - Membrane dynamicselodie.phommabouth1@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616
Corinne Sagné, Research Scientist, INSERM, Team 4 - Membrane dynamicscorinne.sagne@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 16, room 616
Recent Publications
Articles
- Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
Gasnier B : Proc Natl Acad Sci U S A, 2021 - Free sialic acid storage disorder: Progress and promise.
Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021 - Transporters in acidic organelles.
Moriyama Y, Gasnier B : Biochim Biophys Acta Biomembr, 2020 - Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020 - Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn.
Houdou M, Lebredonchel E, Garat A, Duvet S, Legrand D, Decool V, Klein A, Ouzzine M, Gasnier B, Potelle S, Foulquier F : FASEB J, 2019 - Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E.
Liang C, Carrel D, Omelchenko A, Kim H, Patel A, Fanget I, Firestein BL : Cereb Cortex, 2018 - Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLOS ONE, 2017 - Meeting after meeting: 20 years of discoveries by the members of the Exocytosis-Endocytosis Club.
Niedergang F, Gasman S, Vitale N, Desnos C, Lamaze C : Biol Cell, 2017 - Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.
Soltani A, Lebrun S, Carpentier G, Zunino G, Chantepie S, Maïza A, Bozzi Y, Desnos C, Darchen F, Stettler O : PLoS One, 2017 - Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017 - SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017 - Superresolving dendritic spine morphology with STED microscopy under holographic photostimulation.
Lauterbach MA, Guillon M, Desnos C, Khamsing D, Jaffal Z, Darchen F, Emiliani V : Neurophotonics, 2016 - Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter.
Gasnier B : Biophys J, 2016
Book
- Ion and Molecule Transport in Lysosomes
Bruno Gasnier, Michael X Zhu : CRC Press, Taylor & Francis Group, ISBN:9781138560390, (239 pages), 2020
Chapter
- Functional Study of Lysosomal Nutrient Transporters
Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021