To stay in good health, cells that no longer divide such as neurons renew their components by degrading them and recycling their building blocks in acidic compartments called lysosomes. These “micro-stomachs” also work as sensors and integrators of internal and external cues to coordinate cell responses. A study by Team 4 published in PNAS shows how the recycling and sensor functions work together within a single protein in the lysosome membrane.
Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
Xavier Leray, Rossella Conti, Yan Li, Cécile Debacker, Florence Castelli, François Fenaille, Anselm A. Zdebik, Michael Pusch & Bruno Gasnier
PNAS 10 aout 2021 . https://doi.org/10.1073/pnas.2025315118