The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).

Recent Publications

Articles

• Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
  Manuel M, Zytnicki D : Current Opinion in Physiology, 2019
• Scaling of Motor Output, From Mouse to Humans.
  Manuel M, Chardon M, Tysseling V, Heckman CJ : Physiology (Bethesda), 2019
• Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
  Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018
• Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.
  Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C : Sci Rep, 2018
• Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
  Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018
• Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
  Legay C : Ann N Y Acad Sci, 2018
• Constitutive activity of 5-HT receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment.
  Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC : J Neurophysiol, 2017
• PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.
  Huh S, Siripuram R, Lee RH, Turkin VV, O\\’Neill D, Hamm TM, Heckman CJ, Manuel M : J Neurophysiol, 2017
• Decerebrate mouse model for studies of the spinal cord circuits.
  Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ : Nat Protoc, 2017
• Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
  Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017
• Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
  Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L : Development, 2017
• Moving forward with the neuromuscular junction.
  Legay C, Mei L : J Neurochem, 2017
• Absence of UCHL 1 function leads to selective motor neuropathy.
  Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH : Ann Clin Transl Neurol, 2016
• Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.
  Sigoillot SM, Bourgeois F, Karmouch J, Molgó J, Dobbertin A, Chevalier C, Houlgatte R, Léger J, Legay C : FASEB J, 2016
• Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer.
  Destouches D, Sader M, Terry S, Marchand C, Maillé P, Soyeux P, Carpentier G, Semprez F, Céraline J, Allory Y, Courty J, De La Taille A, Vacherot F : Oncotarget, 2016
• Implication de la molécule X dans la récidive du cancer de prostate (CaP) localisé.
  Champy C, Semprez F, El Sayed I, Maille P, Soyeux P, Allory Y, Vacherot F, De La Taille A, Firlej V : Prog Urol, 2015
• CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities.
  Terry S, El-Sayed IY, Destouches D, Maillé P, Nicolaiew N, Ploussard G, Semprez F, Pimpie C, Beltran H, Londono-Vallejo A, Allory Y, de la Taille A, Salomon DS, Vacherot F : Oncotarget, 2015
• Clinical value of ERG, TFF3, and SPINK1 for molecular subtyping of prostate cancer.
  Terry S, Nicolaiew N, Basset V, Semprez F, Soyeux P, Maillé P, Vacherot F, Ploussard G, Londoño-Vallejo A, de la Taille A, Allory Y : Cancer, 2015
• A critical and previously unsuspected role for doublecortin at the neuromuscular junction in mouse and human.
  Bourgeois F, Messéant J, Kordeli E, Petit JM, Delers P, Bahi-Buisson N, Bernard V, Sigoillot SM, Gitiaux C, Stouffer M, Francis F, Legay C : Neuromuscul Disord, 2015
• HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation.
  Joassard OR, Bélanger G, Karmouch J, Lunde JA, Shukla AH, Chopard A, Legay C, Jasmin BJ : J Neurosci, 2015
• Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique.
  Toli D, Buttigieg D, Blanchard S, Lemonnier T, Lamotte d’Incamps B, Bellouze S, Baillat G, Bohl D, Haase G : Neurobiol Dis, 2015
• Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents Ih and ISK.
  Perry S, Gezelius H, Larhammar M, Hilscher MM, Lamotte d’Incamps B, Leao KE, Kullander K : Eur J Neurosci, 2015
• Is hyperexcitability really guilty in amyotrophic lateral sclerosis?
  Leroy F, Zytnicki D : Neural Regen Res, 2015
• Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice.
  Leroy F, Lamotte d’Incamps B, Zytnicki D : J Neurophysiol, 2015
• MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.
  Messéant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgó J, Zytnicki D, Schaeffer L, Legay C, Strochlic L : J Neurosci, 2015
• Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
  Hébert B, Pietropaolo S, Même S, Laudier B, Laugeray A, Doisne N, Quartier A, Lefeuvre S, Got L, Cahard D, Laumonnier F, Crusio WE, Pichon J, Menuet A, Perche O, Briault S : Orphanet J Rare Dis, 2014
• Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis.
  Leroy F, Lamotte d’Incamps B, Imhoff-Manuel RD, Zytnicki D : Elife, 2014
• Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis
  Delestrée N, Manuel M, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D : J Physiol, 2014
• The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons
  Manuel M, Zytnicki D, Meunier C : Front Comput Neurosci, 2014
• Characterization of motor units in behaving adult mice shows a wide primary range
  Ritter LK, Tresch MC, Heckman CJ, Manuel M, Tysseling VM : J Neurophysiol, 2014
• High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses
  d’Incamps BL, Ascher P : J Physiol, 2014