Team 3 – Motor Neurons & NeuroMuscular Junctions
The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).
Team leaders
Boris Lamotte d’Incamps, Research Scientist, PI, CNRS, Team 3 - Motor Neurons & NeuroMuscular Junctionsboris.lamotte-incamps@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 43, room H333B
Daniel Zytnicki, Senior Research Scientist, PI, CNRS, Team 3 - Motor Neurons & NeuroMuscular Junctionsdaniel.zytnicki@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 41, room H345A
Members
Guillaume Caron, Postdoctoral Researcher, Team 3 - Motor Neurons & NeuroMuscular Junctionsguillaume.caron@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09, room H343B
Alexandre Dobbertin, Assistant Professor, University of Paris, Team 3 - Motor Neurons & NeuroMuscular Junctionsalexandre.dobbertin@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 43 54, room H439
Anthony Harster, Assistant Engineer, Team 3 - Motor Neurons & NeuroMuscular Junctions+33 1 76 53 42 09, room H343B
Claire Legay, Professor, University of Paris, Team 3 - Motor Neurons & NeuroMuscular Junctionsclaire.legay@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 20 68, room H444
Fannie Semprez, Assistant engineer, University of Paris, Team 3 - Motor Neurons & NeuroMuscular Junctionsfannie.semprez@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 40 95, room H441
Former members
Marcin Bączyk, Postdoctoral Researcher until 2016, Team 3 - Motor Neurons & NeuroMuscular Junctionsbaczyk@-Code to remove to avoid SPAM-awf.poznan.pl
Marin Manuel, Research Scientist, CNRS until 2021, Team 3 - Motor Neurons & NeuroMuscular Junctionsmmanuel@-Code to remove to avoid SPAM-uri.edu, +33 1 42 86 33 56- Rebecca Manuel, Engineer, CNRS until 2021, Team 3 - Motor Neurons & NeuroMuscular Junctionsrebecca.manuel@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09
Lourdes Martinez-Silva, Postdoctoral Researcher until 2018, Team 3 - Motor Neurons & NeuroMuscular Junctions
Recent Publications
Articles
- Comments on the article by Jensen et al. (2020).
Manuel M, Zytnicki D : J Physiol, 2021 - Synaptic disruption and CREB-regulated transcription are restored by K channel blockers in ALS.
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA, Roselli F, Böckers TM : EMBO Mol Med, 2021 - Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
Bączyk M, Krutki P, Zytnicki D : Physiol Rep, 2021 - Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.
Bilchak J, Yeakle K, Caron G, Malloy D, Côté MP : Exp Neurol, 2021 - A Citrus Based Sensory Functional Food Ingredient Induces Antidepressant-like Effects: Possible Involvement of an Interplay between the Olfactory and the Serotonergic Systems.
Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP : Neuroscience, 2020 - Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.
Caron G, Bilchak JN, Côté MP : J Physiol, 2020 - Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020 - Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
Manuel M, Zytnicki D : Current Opinion in Physiology, 2019 - Alteration of Metabosensitive Afferent Response With Aging: Exercised versus Non-exercised Rats.
Caron G, Decherchi P, Marqueste T : Front Aging Neurosci, 2018 - Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018 - Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018 - Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
Legay C : Ann N Y Acad Sci, 2018 - Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017 - Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L : Development, 2017 - Moving forward with the neuromuscular junction.
Legay C, Mei L : J Neurochem, 2017 - Restoration of post-activation depression of the H-reflex by treadmill exercise in aged rats
Caron G, Marqueste T, Decherchi P : Neurobiol Aging, 2016 - Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.
Sigoillot SM, Bourgeois F, Karmouch J, Molgó J, Dobbertin A, Chevalier C, Houlgatte R, Léger J, Legay C : FASEB J, 2016 - Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer.
Destouches D, Sader M, Terry S, Marchand C, Maillé P, Soyeux P, Carpentier G, Semprez F, Céraline J, Allory Y, Courty J, De La Taille A, Vacherot F : Oncotarget, 2016