The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).

Recent Publications

Articles

• Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
  Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020
• Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
  Manuel M, Zytnicki D : Current Opinion in Physiology, 2019
• Scaling of Motor Output, From Mouse to Humans.
  Manuel M, Chardon M, Tysseling V, Heckman CJ : Physiology (Bethesda), 2019
• Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
  Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018
• Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.
  Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C : Sci Rep, 2018
• Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
  Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018
• Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
  Legay C : Ann N Y Acad Sci, 2018
• Constitutive activity of 5-HT receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment.
  Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC : J Neurophysiol, 2017
• PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.
  Huh S, Siripuram R, Lee RH, Turkin VV, O\\’Neill D, Hamm TM, Heckman CJ, Manuel M : J Neurophysiol, 2017
• Decerebrate mouse model for studies of the spinal cord circuits.
  Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ : Nat Protoc, 2017
• Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
  Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017
• Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
  Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L : Development, 2017
• Moving forward with the neuromuscular junction.
  Legay C, Mei L : J Neurochem, 2017
• Absence of UCHL 1 function leads to selective motor neuropathy.
  Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH : Ann Clin Transl Neurol, 2016
• Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.
  Sigoillot SM, Bourgeois F, Karmouch J, Molgó J, Dobbertin A, Chevalier C, Houlgatte R, Léger J, Legay C : FASEB J, 2016
• Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer.
  Destouches D, Sader M, Terry S, Marchand C, Maillé P, Soyeux P, Carpentier G, Semprez F, Céraline J, Allory Y, Courty J, De La Taille A, Vacherot F : Oncotarget, 2016