The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).

Former members

Recent Publications

Articles

• Bumetanide increases postsynaptic inhibition after chronic SCI and decreases presynaptic inhibition with step-training.
  Caron G, Bilchak J, Côté MP : J Physiol, 2023
• Data clustering analysis of scanning ultrafast acoustic experiments. How acoustic and structural properties of a motoneuron are revealed
  Péronne E, Sénépart O, Legay C, Semprez F, Hamraoui A, Belliard L : {Physical Review Applied}, 2022
• Adhesion energy modulation acts as an NGF receptor activator for neuronal differentiation in NGF-free medium
  Sénépart O, Legay C, Hélary C, Hamraoui A : Advanced Materials Interfaces, 2022
• {Data clustering analysis of scanning ultrafast acoustic experiments. How acoustic and structural properties of a motoneuron are revealed}
  Peronne E, Senepart O, Legay C, Semprez F, Hamraoui A, Belliard L : {Physical Review Applied}, 2022
• The SELENOT mimetic PSELT promotes nerve regeneration by increasing axonal myelination in a facial nerve injury model in female rats.
  Pothion H, Lihrmann I, Duclos C, Riou G, Cartier D, Boukhzar L, Lefranc B, Leprince J, Guérout N, Marie JP, Anouar Y : J Neurosci Res, 2022
• Correlative Imaging of Motoneuronal Cell Elasticity by Pump and Probe Spectroscopy.
  Hamraoui A, Sénépart O, Schneider M, Malaquin S, Péronne E, Becerra L, Semprez F, Legay C, Belliard L : Biophys J, 2021
• Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats.
  Robac A, Neveu P, Hugede A, Garrido E, Nicol L, Delarue Q, Guérout N : Biomedicines, 2021
• RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate.
  Chevreau R, Ghazale H, Ripoll C, Chalfouh C, Delarue Q, Hemonnot-Girard AL, Mamaeva D, Hirbec H, Rothhut B, Wahane S, Perrin FE, Noristani HN, Guerout N, Hugnot JP : Cells, 2021
• Plasticity of the Injured Spinal Cord.
  Guérout N : Cells, 2021
• Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice.
  Delarue Q, Robac A, Massardier R, Marie JP, Guérout N : J Neurosci Res, 2021
• Spinal cord injury: can we repair spinal cord non-invasively by using magnetic stimulation?
  Delarue Q, Chalfouh C, Guérout N : Neural Regen Res, 2021
• Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury.
  Bilchak JN, Caron G, Côté MP : Int J Mol Sci, 2021
• Comments on the article by Jensen et al. (2020).
  Manuel M, Zytnicki D : J Physiol, 2021
• Synaptic disruption and CREB-regulated transcription are restored by K channel blockers in ALS.
  Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA, Roselli F, Böckers TM : EMBO Mol Med, 2021
• Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
  Bączyk M, Krutki P, Zytnicki D : Physiol Rep, 2021
• Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.
  Bilchak J, Yeakle K, Caron G, Malloy D, Côté MP : Exp Neurol, 2021
• AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.
  Karmouch J, Delers P, Semprez F, Soyed N, Areias J, Bélanger G, Ravel-Chapuis A, Dobbertin A, Jasmin BJ, Legay C : Front Mol Neurosci, 2020
• Collagens at the vertebrate neuromuscular junction, from structure to pathologies.
  Legay C, Dobbertin A : Neurosci Lett, 2020
• Building neuromuscular junctions in vitro.
  Barbeau S, Tahraoui-Bories J, Legay C, Martinat C : Development, 2020
• Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ.
  Barbeau S, Desprat R, Eymard B, Martinat C, Lemaitre JM, Legay C : Stem Cell Res, 2020
• Syngeneic Transplantation of Rat Olfactory Stem Cells in a Vein Conduit Improves Facial Movements and Reduces Synkinesis after Facial Nerve Injury.
  Bense F, Montava M, Duclos C, Bisson A, Delarue Q, Mardion NB, Boyer O, Féron F, Guérout N, Marie JP : Plast Reconstr Surg, 2020
• The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
  Karaca E, Li X, Lewicki J, Neofytou C, Guérout N, Barnabé-Heider F, Hermanson O : Mol Cell Neurosci, 2020
• Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
  Delarue Q, Mayeur A, Chalfouh C, Honoré A, Duclos C, Di Giovanni M, Li X, Salaun M, Dampierre J, Vaudry D, Marie JP, Guérout N : J Neurotrauma, 2020
• The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
  Chalfouh C, Guillou C, Hardouin J, Delarue Q, Li X, Duclos C, Schapman D, Marie JP, Cosette P, Guérout N : Neurotherapeutics, 2020
• A Citrus Based Sensory Functional Food Ingredient Induces Antidepressant-like Effects: Possible Involvement of an Interplay between the Olfactory and the Serotonergic Systems.
  Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP : Neuroscience, 2020
• Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.
  Caron G, Bilchak JN, Côté MP : J Physiol, 2020
• Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
  Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020
• Picosecond ultrasounds as elasticity probes in neuron-like cells models
  Viel A, Péronne E, Sénépart O, Becerra L, Legay C, Semprez F, Trichet L, Coradin T, Hamraoui A, Belliard L : Applied Physics Letters, 2019
• Dual innervation may occur in a partially denervated muscle.
  Obongo R, Bon-Mardion N, Duclos C, Strunski V, Guerout N, Marie JP : Muscle Nerve, 2019
• pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy.
  Bergua C, Chiavelli H, Allenbach Y, Arouche-Delaperche L, Arnoult C, Bourdenet G, Jean L, Zoubairi R, Guerout N, Mahler M, Benveniste O, Drouot L, Boyer O : Ann Rheum Dis, 2019
• Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
  Manuel M, Zytnicki D : Current Opinion in Physiology, 2019
• Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.
  Lamotte d’Incamps B, Zorbaz T, Dingova D, Krejci E, Ascher P : J Neurosci, 2018
• Ice-templating beet-root pectin foams: Controlling texture, mechanics and capillary properties
  Sarah Christoph, Ahmed Hamraoui, Estelle Bonnin, Catherine Garnier, Thibaud Coradin, Francisco M Fernandes : Chemical Engineering Journal, 2018
• FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential.
  Li X, Floriddia EM, Toskas K, Chalfouh C, Honore A, Aumont A, Vallières N, Lacroix S, Fernandes KJL, Guérout N, Barnabé-Heider F : Exp Cell Res, 2018
• Alteration of Metabosensitive Afferent Response With Aging: Exercised versus Non-exercised Rats.
  Caron G, Decherchi P, Marqueste T : Front Aging Neurosci, 2018
• Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
  Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018
• Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
  Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018
• Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
  Legay C : Ann N Y Acad Sci, 2018

Chapters

• De la molécule au neurone
  Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023
• De la molécule au neurone
  Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023
• From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis
  Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 375-394, ISBN:978-3-031-07167-6, 2022
• Diversity of Mammalian Motoneurons and Motor Units
  Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 131-150, ISBN:978-3-031-07167-6, 2022

Speech communications

• Extracting Weak Signal with the Help of Data Clustering: Application to Motoneuron Adhesion
  Emmanuel Péronne, Sophie Malaquin, Loic Becerra, Laurent Belliard, Ahmed Hamraoui, Claire Legay, Fannie Semprez : Forum Acusticum, Lyon, France, 2020
• Picosecond ultrasounds as elasticity probes in neuron-like cells models.
  Laurent Belliard, Alexis Viel, Emmanuel Péronne, Océane Sénépart, Loic Becerra, Claire Legay, Fannie Semprez, Lea Trichet, Thibaud Coradin, Ahmed Hamraoui : Forum Acusticum, Lyon, France, 2020