The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).

Former members

Recent Publications

Articles

• The SELENOT mimetic PSELT promotes nerve regeneration by increasing axonal myelination in a facial nerve injury model in female rats.
  Pothion H, Lihrmann I, Duclos C, Riou G, Cartier D, Boukhzar L, Lefranc B, Leprince J, Guérout N, Marie JP, Anouar Y : J Neurosci Res, 2022
• Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats.
  Robac A, Neveu P, Hugede A, Garrido E, Nicol L, Delarue Q, Guérout N : Biomedicines, 2021
• RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate.
  Chevreau R, Ghazale H, Ripoll C, Chalfouh C, Delarue Q, Hemonnot-Girard AL, Mamaeva D, Hirbec H, Rothhut B, Wahane S, Perrin FE, Noristani HN, Guerout N, Hugnot JP : Cells, 2021
• Plasticity of the Injured Spinal Cord.
  Guérout N : Cells, 2021
• Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice.
  Delarue Q, Robac A, Massardier R, Marie JP, Guérout N : J Neurosci Res, 2021
• Spinal cord injury: can we repair spinal cord non-invasively by using magnetic stimulation?
  Delarue Q, Chalfouh C, Guérout N : Neural Regen Res, 2021
• Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury.
  Bilchak JN, Caron G, Côté MP : Int J Mol Sci, 2021
• Comments on the article by Jensen et al. (2020).
  Manuel M, Zytnicki D : J Physiol, 2021
• Synaptic disruption and CREB-regulated transcription are restored by K channel blockers in ALS.
  Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA, Roselli F, Böckers TM : EMBO Mol Med, 2021
• Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
  Bączyk M, Krutki P, Zytnicki D : Physiol Rep, 2021
• Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.
  Bilchak J, Yeakle K, Caron G, Malloy D, Côté MP : Exp Neurol, 2021
• Syngeneic Transplantation of Rat Olfactory Stem Cells in a Vein Conduit Improves Facial Movements and Reduces Synkinesis after Facial Nerve Injury.
  Bense F, Montava M, Duclos C, Bisson A, Delarue Q, Mardion NB, Boyer O, Féron F, Guérout N, Marie JP : Plast Reconstr Surg, 2020
• The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
  Karaca E, Li X, Lewicki J, Neofytou C, Guérout N, Barnabé-Heider F, Hermanson O : Mol Cell Neurosci, 2020
• Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
  Delarue Q, Mayeur A, Chalfouh C, Honoré A, Duclos C, Di Giovanni M, Li X, Salaun M, Dampierre J, Vaudry D, Marie JP, Guérout N : J Neurotrauma, 2020
• The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
  Chalfouh C, Guillou C, Hardouin J, Delarue Q, Li X, Duclos C, Schapman D, Marie JP, Cosette P, Guérout N : Neurotherapeutics, 2020
• A Citrus Based Sensory Functional Food Ingredient Induces Antidepressant-like Effects: Possible Involvement of an Interplay between the Olfactory and the Serotonergic Systems.
  Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP : Neuroscience, 2020
• Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.
  Caron G, Bilchak JN, Côté MP : J Physiol, 2020
• Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
  Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020
• Dual innervation may occur in a partially denervated muscle.
  Obongo R, Bon-Mardion N, Duclos C, Strunski V, Guerout N, Marie JP : Muscle Nerve, 2019
• pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy.
  Bergua C, Chiavelli H, Allenbach Y, Arouche-Delaperche L, Arnoult C, Bourdenet G, Jean L, Zoubairi R, Guerout N, Mahler M, Benveniste O, Drouot L, Boyer O : Ann Rheum Dis, 2019
• Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
  Manuel M, Zytnicki D : Current Opinion in Physiology, 2019
• FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential.
  Li X, Floriddia EM, Toskas K, Chalfouh C, Honore A, Aumont A, Vallières N, Lacroix S, Fernandes KJL, Guérout N, Barnabé-Heider F : Exp Cell Res, 2018
• Alteration of Metabosensitive Afferent Response With Aging: Exercised versus Non-exercised Rats.
  Caron G, Decherchi P, Marqueste T : Front Aging Neurosci, 2018
• Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
  Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018
• Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
  Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018
• Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
  Legay C : Ann N Y Acad Sci, 2018
• Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
  Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017
• Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
  Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L : Development, 2017
• Moving forward with the neuromuscular junction.
  Legay C, Mei L : J Neurochem, 2017

Chapters

• From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis
  Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 375-394, ISBN:978-3-031-07167-6, 2022
• Diversity of Mammalian Motoneurons and Motor Units
  Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 131-150, ISBN:978-3-031-07167-6, 2022