The members of this new group, from three diferent teams, have worked together for a long time on cerebellar neurophysiology and the development of optical tools for Neuroscience with a strong common interest in the biophysics of synaptic transmission and how it is integrated by the cerebellar cortex microcircuit to generate output. They will combine complementary technical expertise in cerebellar physiology in order to understand how the cerebellar cortex transforms simple stimuli into meaningful patterns of activity in populations of Purkinje cells and the resulting effect on simple learned behaviors.

Recent Publications

Articles

• A Structural Model of the Inactivation Gate of Voltage Activated Potassium Channels.
  Vergara-Jaque A, Palma-Cerda F, Lowet AS, de la Cruz Landrau A, Poblete H, Sukharev A, Comer J, Holmgren M : Biophys J, 2019
• Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-Caged -D-Glutamyl-Glycine, to Investigate Transmitter Dynamics and Receptor Properties at Glutamatergic Synapses.
  Palma-Cerda F, Papageorgiou G, Barbour B, Auger C, Ogden D : Front Cell Neurosci, 2018
• Quantal Fluctuations in Central Mammalian Synapses: Functional Role of Vesicular Docking Sites.
  Pulido C, Marty A : Physiol Rev, 2017
• Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses.
  Miki T, Kaufmann WA, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R, Marty A : Proc Natl Acad Sci U S A, 2017
• Concerted Interneuron Activity in the Cerebellar Molecular Layer During Rhythmic Oromotor Behaviors.
  Astorga G, Li D, Therreau L, Kassa M, Marty A, Llano I : J Neurosci, 2017
• Axonal GABAA receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells.
  Zorrilla de San Martin J, Trigo FF, Kawaguchi SY : J Physiol, 2017
• Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
  Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017
• Quinoline-Derived Two-Photon Sensitive Quadrupolar Probes.
  Tran C, Berqouch N, Dhimane H, Clermont G, Blanchard-Desce M, Ogden D, Dalko PI : Chemistry, 2017
• Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells.
  Ramirez JE, Stell BM : Cell Rep, 2016
• Photolysis quantum yield measurements in the near-UV; a critical analysis of 1-(2-nitrophenyl)ethyl photochemistry.
  Corrie JE, Kaplan JH, Forbush B, Ogden DC, Trentham DR : Photochem Photobiol Sci, 2016
• Calcium imaging reveals coordinated simple spike pauses in populations of Cerebellar Purkinje cells
  Ramirez JE, Stell BM : BioRxiv, 2016
• Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis.
  Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A : Neuron, 2016
• Train stimulation of parallel fibre to Purkinje cell inputs reveals two populations of synaptic responses with different receptor signatures.
  Devi SP, Howe JR, Auger C : J Physiol, 2016
• Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses.
  Malagon G, Miki T, Llano I, Neher E, Marty A : J Neurosci, 2016
• Two-photon caging groups: effect of position isomery on the photorelease properties of aminoquinoline-derived photolabile protecting groups
  Tran C, Gallavardin T, Petit M, Slimi R, Dhimane H, Blanchard-Desce M, Acher FC, Ogden D, Dalko PI : Org Lett, 2015
• Commentary on Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet-A-Induced Photouncaging by G. Gasser and Co-Workers.
  Corrie JE, Kaplan JH, Forbush B, Ogden DC, Trentham DR : Chemphyschem, 2015
• Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics.
  Helassa N, Zhang XH, Conte I, Scaringi J, Esposito E, Bradley J, Carter T, Ogden D, Morad M, Török K : Sci Rep, 2015
• Expression and cellular function of vSNARE proteins in brain astrocytes.
  Ropert N, Jalil A, Li D : Neuroscience, 2015
• Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.
  Zorrilla de San Martín J, Jalil A, Trigo FF : J Gen Physiol, 2015
• An excitatory GABA loop operating in vivo.
  Astorga G, Bao J, Marty A, Augustine GJ, Franconville R, Jalil A, Bradley J, Llano I : Front Cell Neurosci, 2015
• Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses
  Pulido C, Trigo FF, Llano I, Marty A : Neuron, 2015
• Quinoline-derived two-photon sensitive quadrupolar probes.
  Dunkel P, Tran C, Gallavardin T, Dhimane H, Ogden D, Dalko PI : Org Biomol Chem, 2014
• Synthesis and biological evaluation of bis-CNB-GABA, a photoactivatable neurotransmitter with low receptor interference and chemical two-photon uncaging properties.
  Shi DD, Trigo FF, Semmelhack MF, Wang SS : J Am Chem Soc, 2014
• High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses
  d’Incamps BL, Ascher P : J Physiol, 2014