The members of the Cerebellar Physiology team are working together to unravel the role of the cerebellum in sensorimotor integration, from synaptic to systems levels. We use our strong interest in neurophysiology and development of optical tools for neuroscience to explore the biophysics of synaptic transmission and how it is integrated by the cerebellar cortex microcircuit during sensorimotor integration in awake behaving animals. Our team combines complementary technical expertise in cerebellar physiology ranging from single synapse electrophysiology up to imaging populations of neurons in mice performing cerebellar-dependent motor tasks.

Recent Publications

Articles

• Prioritized docking of synaptic vesicles provided by a rapid recycling pathway
  Tran V, Silva M, Marty A : IScience, in press
• Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum.
  Le Guellec B, Gomez LC, Malagon G, Collin T, Marty A : J Gen Physiol, 2023
• KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.
  Kassa M, Bradley J, Jalil A, Llano I : J Gen Physiol, 2023
• The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK.
  Boëx M, Cottin S, Halliez M, Bauché S, Buon C, Sans N, Montcouquiol M, Molgó J, Amar M, Ferry A, Lemaitre M, Rouche A, Langui D, Baskaran A, Fontaine B, Messéant J, Strochlic L : Sci Signal, 2022
• A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex.
  Chindemi G, Abdellah M, Amsalem O, Benavides-Piccione R, Delattre V, Doron M, Ecker A, Jaquier AT, King J, Kumbhar P, Monney C, Perin R, Rössert C, Tuncel AM, Van Geit W, DeFelipe J, Graupner M, Segev I, Markram H, Muller EB : Nat Commun, 2022
• Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing.
  Andrianarivelo A, Saint-Jour E, Pousinha P, Fernandez SP, Petitbon A, De Smedt-Peyrusse V, Heck N, Ortiz V, Allichon MC, Kappès V, Betuing S, Walle R, Zhu Y, Joséphine C, Bemelmans AP, Turecki G, Mechawar N, Javitch JA, Caboche J, Trifilieff P, Barik J, Vanhoutte P : Sci Adv, 2021
• Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons.
  Forget B, Garcia EM, Godino A, Rodriguez LD, Kappes V, Poirier P, Andrianarivelo A, Marchan ES, Allichon MC, Marias M, Vanhoutte P, Girault JA, Maldonado R, Caboche J : Mol Psychiatry, 2021
• Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion.
  Lissek T, Andrianarivelo A, Saint-Jour E, Allichon MC, Bauersachs HG, Nassar M, Piette C, Pruunsild P, Tan YW, Forget B, Heck N, Caboche J, Venance L, Vanhoutte P, Bading H : EMBO Rep, 2021
• Calcium-dependent docking of synaptic vesicles.
  Silva M, Tran V, Marty A : Trends Neurosci, 2021
• Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
  Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021
• Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors.
  Giribaldi J, Haufe Y, Evans ERJ, Amar M, Durner A, Schmidt C, Faucherre A, Moha Ou Maati H, Enjalbal C, Molgó J, Servent D, Wilson DT, Daly NL, Nicke A, Dutertre S : J Med Chem, 2020
• Beyond Freezing: Temporal Expectancy of an Aversive Event Engages the Amygdalo-Prefronto-Dorsostriatal Network.
  Tallot L, Graupner M, Diaz-Mataix L, Doyère V : Cereb Cortex, 2020
• Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity.
  Deperrois N, Graupner M : PLoS Comput Biol, 2020
• YIF1B mutations cause a post-natal neurodevelopmental syndrome associated with Golgi and primary cilium alterations.
  Diaz J, Gérard X, Emerit MB, Areias J, Geny D, Dégardin J, Simonutti M, Guerquin MJ, Collin T, Viollet C, Billard JM, Métin C, Hubert L, Larti F, Kahrizi K, Jobling R, Agolini E, Shaheen R, Zigler A, Rouiller-Fabre V, Rozet JM, Picaud S, Novelli A, Alameer S, Najmabadi H, Cohn R, Munnich A, Barth M, Lugli L, Alkuraya FS, Blaser S, Gashlan M, Besmond C, Darmon M, Masson J : Brain, 2020
• Molecular layer interneurons in the cerebellum encode for valence in associative learning.
  Ma M, Futia GL, de Souza FMS, Ozbay BN, Llano I, Gibson EA, Restrepo D : Nat Commun, 2020
• Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons.
  Rey S, Maton G, Satake S, Llano I, Kang S, Surmeier DJ, Silverman RB, Collin T : J Neurochem, 2020
• Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo.
  Bao J, Graupner M, Astorga G, Collin T, Jalil A, Indriati DW, Bradley J, Shigemoto R, Llano I : Elife, 2020
• Incomplete vesicular docking limits synaptic strength under high release probability conditions.
  Malagon G, Miki T, Tran V, Gomez LC, Marty A : Elife, 2020
• Differentially poised vesicles underlie fast and slow components of release at single synapses.
  Blanchard K, Zorrilla de San Martín J, Marty A, Llano I, Trigo FF : J Gen Physiol, 2020
• Influence of spatially segregated IP-producing pathways on spike generation and transmitter release in Purkinje cell axons.
  Gomez LC, Kawaguchi SY, Collin T, Jalil A, Gomez MDP, Nasi E, Marty A, Llano I : Proc Natl Acad Sci U S A, 2020
• Dp71-Dystrophin Deficiency Alters Prefrontal Cortex Excitation-Inhibition Balance and Executive Functions.
  Chaussenot R, Amar M, Fossier P, Vaillend C : Mol Neurobiol, 2019
• Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology.
  Taiwe GS, Montnach J, Nicolas S, De Waard S, Fiore E, Peyrin E, El-Aziz TMA, Amar M, Molgó J, Ronjat M, Servent D, Ravelet C, De Waard M : Molecules, 2019
• A multiscale analysis in CD38(-/-) mice unveils major prefrontal cortex dysfunctions.
  Martucci LL, Amar M, Chaussenot R, Benet G, Bauer O, de Zélicourt A, Nosjean A, Launay JM, Callebert J, Sebrié C, Galione A, Edeline JM, de la Porte S, Fossier P, Granon S, Vaillend C, Cancela JM : FASEB J, 2019
• Cortical recruitment determines learning dynamics and strategy.
  Ceballo S, Bourg J, Kempf A, Piwkowska Z, Daret A, Pinson P, Deneux T, Rumpel S, Bathellier B : Nat Commun, 2019
• Targeted Cortical Manipulation of Auditory Perception.
  Ceballo S, Piwkowska Z, Bourg J, Daret A, Bathellier B : Neuron, 2019
• Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations.
  Andrianarivelo A, Saint-Jour E, Walle R, Trifilieff P, Vanhoutte P : Neuropharmacology, 2019
• Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice.
  Villette V, Chavarha M, Dimov IK, Bradley J, Pradhan L, Mathieu B, Evans SW, Chamberland S, Shi D, Yang R, Kim BB, Ayon A, Jalil A, St-Pierre F, Schnitzer MJ, Bi G, Toth K, Ding J, Dieudonné S, Lin MZ : Cell, 2019
• Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors.
  Amar M, Aráoz R, Iorga BI, Yasumoto T, Servent D, Molgó J : Toxins (Basel), 2018
• Direct evidence for high affinity blockade of Na(V)1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches.
  Gonçalves TC, Boukaiba R, Molgó J, Amar M, Partiseti M, Servent D, Benoit E : Neuropharmacology, 2018
• Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-Caged -D-Glutamyl-Glycine, to Investigate Transmitter Dynamics and Receptor Properties at Glutamatergic Synapses.
  Palma-Cerda F, Papageorgiou G, Barbour B, Auger C, Ogden D : Front Cell Neurosci, 2018

Chapter

• Modeling Synaptic Plasticity in Hippocampus: A Calcium-Based Approach
  Graupner M, Brunel N : extracted from Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Cutsuridis V, Graham B, Cobb S, Vida I - Springer Cham, pages 615-644, ISBN:978-1-4419-0996-1, 2018