The members of the Cerebellar Physiology team are working together to unravel the role of the cerebellum in sensorimotor integration, from synaptic to systems levels. We use our strong interest in neurophysiology and development of optical tools for neuroscience to explore the biophysics of synaptic transmission and how it is integrated by the cerebellar cortex microcircuit during sensorimotor integration in awake behaving animals. Our team combines complementary technical expertise in cerebellar physiology ranging from single synapse electrophysiology up to imaging populations of neurons in mice performing cerebellar-dependent motor tasks.

Recent Publications

Articles

• Molecular layer interneurons in the cerebellum encode for valence in associative learning.
  Ma M, Futia GL, de Souza FMS, Ozbay BN, Llano I, Gibson EA, Restrepo D : Nat Commun, 2020
• Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons.
  Rey S, Maton G, Satake S, Llano I, Kang S, Surmeier DJ, Silverman RB, Collin T : J Neurochem, 2020
• Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo.
  Bao J, Graupner M, Astorga G, Collin T, Jalil A, Indriati DW, Bradley J, Shigemoto R, Llano I : Elife, 2020
• Incomplete vesicular docking limits synaptic strength under high release probability conditions.
  Malagon G, Miki T, Tran V, Gomez LC, Marty A : Elife, 2020
• Differentially poised vesicles underlie fast and slow components of release at single synapses.
  Blanchard K, Zorrilla de San Martín J, Marty A, Llano I, Trigo FF : J Gen Physiol, 2020
• Influence of spatially segregated IP-producing pathways on spike generation and transmitter release in Purkinje cell axons.
  Gomez LC, Kawaguchi SY, Collin T, Jalil A, Gomez MDP, Nasi E, Marty A, Llano I : Proc Natl Acad Sci U S A, 2020
• Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations.
  Andrianarivelo A, Saint-Jour E, Walle R, Trifilieff P, Vanhoutte P : Neuropharmacology, 2019
• Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice.
  Villette V, Chavarha M, Dimov IK, Bradley J, Pradhan L, Mathieu B, Evans SW, Chamberland S, Shi D, Yang R, Kim BB, Ayon A, Jalil A, St-Pierre F, Schnitzer MJ, Bi G, Toth K, Ding J, Dieudonné S, Lin MZ : Cell, 2019
• A Structural Model of the Inactivation Gate of Voltage Activated Potassium Channels.
  Vergara-Jaque A, Palma-Cerda F, Lowet AS, de la Cruz Landrau A, Poblete H, Sukharev A, Comer J, Holmgren M : Biophys J, 2019
• Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-Caged -D-Glutamyl-Glycine, to Investigate Transmitter Dynamics and Receptor Properties at Glutamatergic Synapses.
  Palma-Cerda F, Papageorgiou G, Barbour B, Auger C, Ogden D : Front Cell Neurosci, 2018
• Phospho-ERK and sex steroids in the mPOA: involvement in male mouse sexual behaviour.
  Jean A, Trouillet AC, Andrianarivelo NA, Mhaouty-Kodja S, Hardin-Pouzet H : J Endocrinol, 2017
• Quantal Fluctuations in Central Mammalian Synapses: Functional Role of Vesicular Docking Sites.
  Pulido C, Marty A : Physiol Rev, 2017
• Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses.
  Miki T, Kaufmann WA, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R, Marty A : Proc Natl Acad Sci U S A, 2017
• Concerted Interneuron Activity in the Cerebellar Molecular Layer During Rhythmic Oromotor Behaviors.
  Astorga G, Li D, Therreau L, Kassa M, Marty A, Llano I : J Neurosci, 2017
• Axonal GABAA receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells.
  Zorrilla de San Martin J, Trigo FF, Kawaguchi SY : J Physiol, 2017
• Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.
  Lamotte d’Incamps B, Bhumbra GS, Foster JD, Beato M, Ascher P : Sci Rep, 2017
• Quinoline-Derived Two-Photon Sensitive Quadrupolar Probes.
  Tran C, Berqouch N, Dhimane H, Clermont G, Blanchard-Desce M, Ogden D, Dalko PI : Chemistry, 2017
• Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells.
  Ramirez JE, Stell BM : Cell Rep, 2016
• Photolysis quantum yield measurements in the near-UV; a critical analysis of 1-(2-nitrophenyl)ethyl photochemistry.
  Corrie JE, Kaplan JH, Forbush B, Ogden DC, Trentham DR : Photochem Photobiol Sci, 2016
• Calcium imaging reveals coordinated simple spike pauses in populations of Cerebellar Purkinje cells
  Ramirez JE, Stell BM : BioRxiv, 2016
• Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis.
  Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A : Neuron, 2016
• Train stimulation of parallel fibre to Purkinje cell inputs reveals two populations of synaptic responses with different receptor signatures.
  Devi SP, Howe JR, Auger C : J Physiol, 2016
• Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses.
  Malagon G, Miki T, Llano I, Neher E, Marty A : J Neurosci, 2016
• Two-photon caging groups: effect of position isomery on the photorelease properties of aminoquinoline-derived photolabile protecting groups
  Tran C, Gallavardin T, Petit M, Slimi R, Dhimane H, Blanchard-Desce M, Acher FC, Ogden D, Dalko PI : Org Lett, 2015
• Commentary on Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet-A-Induced Photouncaging by G. Gasser and Co-Workers.
  Corrie JE, Kaplan JH, Forbush B, Ogden DC, Trentham DR : Chemphyschem, 2015
• Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics.
  Helassa N, Zhang XH, Conte I, Scaringi J, Esposito E, Bradley J, Carter T, Ogden D, Morad M, Török K : Sci Rep, 2015
• Expression and cellular function of vSNARE proteins in brain astrocytes.
  Ropert N, Jalil A, Li D : Neuroscience, 2015
• Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.
  Zorrilla de San Martín J, Jalil A, Trigo FF : J Gen Physiol, 2015
• An excitatory GABA loop operating in vivo.
  Astorga G, Bao J, Marty A, Augustine GJ, Franconville R, Jalil A, Bradley J, Llano I : Front Cell Neurosci, 2015
• Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses
  Pulido C, Trigo FF, Llano I, Marty A : Neuron, 2015