Nouvel article « Les neurones sont élastiques… » ( article HAL, annonce INSP )

La régénérescence du système nerveux central et périphérique, suite à une pathologie ou un traumatisme, est un enjeu sociétal majeur dans un contexte de vieillissement de la population. Cette plasticité pilotée par la croissance et la différenciation des cellules en neurones par exemple dépend de bons nombres de paramètres. La corrélation entre ces mécanismes de réparation et la réponse élastique de l’environnement et des cellules elles-mêmes est souvent évoquée mais reste encore à ce jour difficilement quantifiable. Néanmoins, des chercheurs de l’INSP en collaboration avec le LCMCP et SPPIN ont franchi une étape cruciale vers cet objectif en quantifiant, à l’échelle micrométrique, les inhomogénéités élastiques au cœur même du neurone.

Recent Publications

Articles

• Data clustering analysis of scanning ultrafast acoustic experiments. How acoustic and structural properties of a motoneuron are revealed
  Péronne E, Sénépart O, Legay C, Semprez F, Hamraoui A, Belliard L : {Physical Review Applied}, 2022
• Adhesion energy modulation acts as an NGF receptor activator for neuronal differentiation in NGF-free medium
  Sénépart O, Legay C, Hélary C, Hamraoui A : Advanced Materials Interfaces, 2022
• Correlative Imaging of Motoneuronal Cell Elasticity by Pump and Probe Spectroscopy.
  Hamraoui A, Sénépart O, Schneider M, Malaquin S, Péronne E, Becerra L, Semprez F, Legay C, Belliard L : Biophys J, 2021
• Picosecond ultrasounds as elasticity probes in neuron-like cells models
  Viel A, Péronne E, Sénépart O, Becerra L, Legay C, Semprez F, Trichet L, Coradin T, Hamraoui A, Belliard L : Applied Physics Letters, 2019
• Ice-templating beet-root pectin foams: Controlling texture, mechanics and capillary properties
  Sarah Christoph, Ahmed Hamraoui, Estelle Bonnin, Catherine Garnier, Thibaud Coradin, Francisco M Fernandes : Chemical Engineering Journal, 2018
• Surface-induced assembly of sophorolipids.
  Peyre J, Hamraoui A, Faustini M, Humblot V, Baccile N : Phys Chem Chem Phys, 2017
• Substrate-induced PC12 cell differentiation without filopodial, lamellipodial activity or NGF stimulationa.
  Lamour G, Souès S, Hamraoui A : Macromol Biosci, 2015
• Tuning surface energy at the nanometer scale: A new step towards controlling neuronal differentiation?
  Lamour G, Souès S, Collart E, Colline S, Bardoue N, Hamraoui A : Journal of Nanoscience Letters, 2013
• Neuritogenesis on antagonist surfaces
  Lamour G, Souès S, Hamraoui A : Global Journal of Physical Chemistry| Volume, 2011
• Interplay between long- and short-range interactions drives neuritogenesis on stiff surfaces.
  Lamour G, Souès S, Hamraoui A : J Biomed Mater Res A, 2011
• Contact angle measurements using a simplified experimental setup
  Lamour G, Hamraoui A, Buvailo A, Xing Y, Keuleyan S, Prakash V, Eftekhari-Bafrooei A, Borguet E : Journal of chemical education, 2010
• Neuronal adhesion and differentiation driven by nanoscale surface free-energy gradients.
  Lamour G, Eftekhari-Bafrooei A, Borguet E, Souès S, Hamraoui A : Biomaterials, 2010
• Influence of surface energy distribution on neuritogenesis.
  Lamour G, Journiac N, Souès S, Bonneau S, Nassoy P, Hamraoui A : Colloids Surf B Biointerfaces, 2009
• Layering and prewetting in experimental systems: an assessment cross-referred to current theories.
  Hamraoui A, Privat M : Adv Colloid Interface Sci, 2009
• Modelling photochemical reactions in atmospheric water droplets: An assessment of the importance of surface processes
  Davide Vione, Claudio Minero, Ahmed Hamraoui, Mireille Privat : Atmospheric Environment, 2007
• Fingering phenomena during spreading of surfactant solutions
  Hamraoui A, Cachile M, Poulard C, Cazabat A : Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2004
• Films driven by surface tension gradients.
  Cachile M, Schneemilch M, Hamraoui A, Cazabat AM : Adv Colloid Interface Sci, 2002
• Analytical approach for the Lucas-Washburn equation.
  Hamraoui A, Nylander T : J Colloid Interface Sci, 2002
• Critical and wetting transitional adsorption behaviour in a liquid system against vapour and other walls
  Huruguen J, Amara M, Méar A, Hamraoui H, Olier R, Privat M : Journal of Physics: Condensed Matter, 2001
• Can a dynamic contact angle be understood in terms of a friction coefficient?
  Hamraoui A, Thuresson K, Nylander T, Yaminsky V : Journal of colloid and interface science, 2000
• Interfacial properties of whey proteins at air/water and oil/water interfaces studied by dynamic drop tensiometry, ellipsometry and spreading kinetics
  Nylander T, Hamraoui A, Paulsson M : International journal of food science \& technology, 1999
• Surface phase transitions at liquid-mixture/solid interfaces
  Mazeas I, P{\’e}lerin P, Sellami H, Hamraoui A, Olier R, Privat M : Langmuir, 1999
• Impact of Bulk Phase Transitions and Wetting Transitions on Adsorption Isotherms in Binary Systems in Contact with Solid.
  Hamraoui A, Privat M : J Colloid Interface Sci, 1998
• Experimental Evidence of Pure Layering at the Solid/Liquid Binary Mixture Interface. Silica/Water- 2, 5-Dimethylpyridine System
  Sellami H, Hamraoui A, Privat M, Olier R : Langmuir, 1998
• Layering in a two-component liquid system undergoing a phase separation
  Hamraoui A, Privat M, Sellami H : The Journal of chemical physics, 1997
• Prewetting transition influenced by layeringlike transitions at a binary liquid/solid interface
  Hamraoui A, Privat M : The Journal of chemical physics, 1997
• Monolayers, critical layers and wetting films in a liquid-liquid-solid system undergoing a wetting transition. Experimental study
  Privat M, Amara M, Hamraoui A, Sellami H, Mear A : Berichte der Bunsengesellschaft f{\, 1994

Chapter

• Dynamic wetting and dewetting by aqueous solutions containing amphiphilic compounds
  Hamraoui Ahmed, Thuresson Krister, Nylander Tommy, Eskilsson Krister, Yaminsky Vassili : extracted from Surface and Colloid Science Valdemaras Razumas, Björn Lindman, Tommy Nylander - Springer, pages 113-119, ISBN:978-3-540-44941-6, 2001

Speech communications

• Extracting Weak Signal with the Help of Data Clustering: Application to Motoneuron Adhesion
  Emmanuel Péronne, Sophie Malaquin, Loic Becerra, Laurent Belliard, Ahmed Hamraoui, Claire Legay, Fannie Semprez : Forum Acusticum, Lyon, France, 2020
• Picosecond ultrasounds as elasticity probes in neuron-like cells models.
  Laurent Belliard, Alexis Viel, Emmanuel Péronne, Océane Sénépart, Loic Becerra, Claire Legay, Fannie Semprez, Lea Trichet, Thibaud Coradin, Ahmed Hamraoui : Forum Acusticum, Lyon, France, 2020

Patent

• Nerve repair implant: International application
  A Hamraoui, O Sénépart, C Legay : Patent # : PCT A B2023/000262, 2023