SPPIN - Saints-Pères Paris Institute for the Neurosciences - CNRS UMR 8003
Université Paris Cité
F-75006 Paris
France

Brigitte Delhomme

Engineer, CNRS
Team 1 - Biophysics of the brain

brigitte.delhomme@-Code to remove to avoid SPAM-u-paris.fr
+33 1 76 53 42 13, room P374A

Recent Publications

Articles

• Imaging the enteric nervous system
  Doriane Hazart, Marwa Moulzir, Brigitte Delhomme, Martin Oheim, Clément Ricard : Front Neuroanat, 2025
• Fast tissue clearing and volume imaging techniques for anatomy
  Clément Ricard, Doriane Hazart, Brigitte Delhomme, Marwa Moulzir, Irina Rakotoson, Martin Oheim : Microscopy Research & Technique (accepted), 2025
• The gut, a whistleblower, in the early stages of Parkinson’s disease
  Doriane Hazart, Malvyne Rolli-Derkinderen, Brigitte Delhomme, Pascal Derkinderen, Martin Oheim, Clément Ricard : Médecine/sciences, 2024
• L’intestin, lanceur d’alerte, dans les prémices de la maladie de Parkinson
  Doriane Hazart, Malvyne Rolli-Derkinderen, Brigitte Delhomme, Pascal Derkinderen, Martin Oheim, Clément Ricard : Médecine/sciences, 2024
• Label-free, fast, 2-photon volume imaging of the organization of neurons and glia in the enteric nervous system.
  Hazart D, Delhomme B, Oheim M, Ricard C : Front Neuroanat, 2022
• A simple, inexpensive and multi-scale 3-D fluorescent test sample for optical sectioning microscopies.
  Olevsko I, Szederkenyi K, Corridon J, Au A, Delhomme B, Bastien T, Fernandes J, Yip C, Oheim M, Salomon A : Microsc Res Tech, 2021
• Fast 3-D Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope.
  Rakotoson I, Delhomme B, Djian P, Deeg A, Brunstein M, Seebacher C, Uhl R, Ricard C, Oheim M : Front Neuroanat, 2019
• Fast 3-D Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope
  Irina Rakotoson, Brigitte Delhomme, Philippe Djian, Andreas Deeg, Maia Brunstein, Christian Seebacher, Rainer Uhl, Clement Ricard, Martin Oheim : Front Neuroanat, 2019
• The importance of basonuclin 2 in adult mice and its relation to basonuclin 1.
  Vanhoutteghem A, Delhomme B, Hervé F, Nondier I, Petit JM, Araki M, Araki K, Djian P : Mech Dev, 2016
• Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model.
  Borriello L, Montès M, Lepelletier Y, Leforban B, Liu WQ, Demange L, Delhomme B, Pavoni S, Jarray R, Boucher JL, Dufour S, Hermine O, Garbay C, Hadj-Slimane R, Raynaud F : Cancer Lett, 2014
• The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells.
  Vanhoutteghem A, Messiaen S, Hervé F, Delhomme B, Moison D, Petit JM, Rouiller-Fabre V, Livera G, Djian P : Development, 2014
• Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.
  Bhoj EJ, Ramos P, Baker LA, Garg V, Cost N, Nordenskjöld A, Elder FF, Bleyl SB, Bowles NE, Arrington CB, Delhomme B, Vanhoutteghem A, Djian P, Zinn AR : Eur J Hum Genet, 2011
• Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.
  Bhoj EJ, Ramos P, Baker LA, Cost N, Nordenskjöld A, Elder FF, Bleyl SB, Bowles NE, Arrington CB, Delhomme B, Vanhoutteghem A, Djian P, Zinn AR : Eur J Hum Genet, 2011
• Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins.
  Vanhoutteghem A, Maciejewski-Duval A, Bouche C, Delhomme B, Hervé F, Daubigney F, Soubigou G, Araki M, Araki K, Yamamura K, Djian P : Proc Natl Acad Sci U S A, 2009
• Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins.
  Vanhoutteghem A, Maciejewski-Duval A, Bouche C, Delhomme B, Hervé F, Daubigney F, Soubigou G, Araki M, Araki K, Yamamura K, Djian P : Proc Natl Acad Sci U S A, 2009
• Systematic repeat addition at a precise location in the coding region of the involucrin gene of wild mice reveals their phylogeny.
  Djian P, Delhomme B : Genetics, 2005
• Expansion of mouse involucrin by intra-allelic repeat addition.
  Delhomme B, Djian P : Gene, 2000
• Origin of the polymorphism of the involucrin gene in Asians.
  Djian P, Delhomme B, Green H : Am J Hum Genet, 1995
• Independent modulation by food supply of two distinct sodium-activated D-glucose transport systems in the guinea pig jejunal brush-border membrane.
  Brot-Laroche E, Dao MT, Alcalde AI, Delhomme B, Triadou N, Alvarado F : Proc Natl Acad Sci U S A, 1988
• Characterization of the D-glucose/Na+ cotransport system in the intestinal brush-border membrane by using the specific substrate, methyl alpha-D-glucopyranoside.
  Brot-Laroche E, Supplisson S, Delhomme B, Alcalde AI, Alvarado F : Biochim Biophys Acta, 1987
• Temperature sensitivity and substrate specificity of two distinct Na+-activated D-glucose transport systems in guinea pig jejunal brush border membrane vesicles.
  Brot-Laroche E, Serrano MA, Delhomme B, Alvarado F : J Biol Chem, 1986
• Heterogenrity of sodium-activated D-Glucose transport system in the intestinal brush border membrane: physiological implications
  Alvarado F, Brot-Laroche E, Delhomme B, Serrano MA, Supplisson S : Bulletin de la Societa Italiana de Biologia Experimental, 1986
• Comparison between starvation and consumption of a high protein diet in rats: hepatic metabolites and amino acid levels during the first 24 hours.
  Bois-Joyeux B, Chanez M, Azzout B, Delhomme B, Peret J : Diabete Metab, 1986
• Different temperature sensitivity and cation specificity of two distinct D-glucose/Na+ cotransport systems in the intestinal brush-border membrane.
  Brot-Laroche E, Serrano MA, Delhomme B, Alvarado F : Ann N Y Acad Sci, 1985
• Metabolic effects of high-protein diets in Zucker rats.
  Peret J, Bach AC, Delhomme B, Bois-Joyeux B, Chanez M, Schirardin H : Metabolism, 1984
• Effects of excess methionine ingestion on hepatic phosphate, adenine nucleotides and free amino acids in the rat.
  Fau D, Chanez M, Bois-Joyeux B, Delhomme B, Peret J : J Nutr, 1982
• Adaptation of hepatic enzyme activities to methionine excess.
  Fau D, Bois-Joyeux B, Chanez M, Delhomme B, Peret J : Reprod Nutr Dev, 1981
• Phosphate,pyrophosphate and adenin nucleotides equilibrium in rat liver after ethionine ingestion and during ischemia
  Fau D, Chanez M, Bois-Joyeux B, Delhomme B, Peret J : Nutrition Report International, 1981
• Long term effects of methionine excess on rat metabolism
  Fau D, Bois-Joyeux B, Delhomme B, Chanez M, Peret J : Nutrition Report International, 1980
• [Enzymatic activities in the liver, and muscle nucleic acids, in swine receiving an unbalanced diet with an excess of methionine for 100 days].
  Fau D, Delhomme B, Bourdon D, Rerat A : C R Seances Acad Sci D, 1980

Speech communications / proceedings

• M-Cube—towards correlative multi-scale light-sheet imaging using a compact, modular and moving illuminator
  Touja H, Brau F, Bastien T, Delhomme B, Oheim M : EPJ Web of Conferences, EDP Sciences, 2024
• Fast, large-field fluorescence and second-harmonic generation imaging with a single-spinning disk two-photon microscope
  Andreas Deeg, Federico Trigo, Doriane Hazart, Brigitte Delhomme, Tchyia Zar, Thomas Naiser, Christian Seebacher, Adi Salomon, Clément Ricard, Rainer Uhl, Martin Oheim : European Optical Society Annual Meeting, Dijon, 2023

Patent

• Composition and method for clearing biological samples
  Brigitte delhomme, Martin Oheim : Patent # : WO2024089224A1, 2024