SPPIN - Saints-Pères Paris Institute for the Neurosciences - CNRS UMR 8003
Université Paris Cité
F-75006 Paris
France

Dr. Michael Graupner

Research Scientist, CNRS
Team 8 - Orientation and Coordination

michael.graupner@-Code to remove to avoid SPAM-u-paris.fr
+33 1 76 53 43 20, room E358

Students :

Elja Belhadef
Marin Dauguet
Clara Rouffiange

• Resume
• Research
• Python & Hardware
• Teaching
• Selected publications

Recent Publications

Articles

• A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex.
  Chindemi G, Abdellah M, Amsalem O, Benavides-Piccione R, Delattre V, Doron M, Ecker A, Jaquier AT, King J, Kumbhar P, Monney C, Perin R, Rössert C, Tuncel AM, Van Geit W, DeFelipe J, Graupner M, Segev I, Markram H, Muller EB : Nat Commun, 2022
• Beyond Freezing: Temporal Expectancy of an Aversive Event Engages the Amygdalo-Prefronto-Dorsostriatal Network.
  Tallot L, Graupner M, Diaz-Mataix L, Doyère V : Cereb Cortex, 2020
• Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity.
  Deperrois N, Graupner M : PLoS Comput Biol, 2020
• Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo.
  Bao J, Graupner M, Astorga G, Collin T, Jalil A, Indriati DW, Bradley J, Shigemoto R, Llano I : Elife, 2020
• Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control.
  Dallérac G, Graupner M, Knippenberg J, Martinez RC, Tavares TF, Tallot L, El Massioui N, Verschueren A, Höhn S, Bertolus JB, Reyes A, LeDoux JE, Schafe GE, Diaz-Mataix L, Doyère V : Nat Commun, 2017
• Natural Firing Patterns Imply Low Sensitivity of Synaptic Plasticity to Spike Timing Compared with Firing Rate.
  Graupner M, Wallisch P, Ostojic S : J Neurosci, 2016
• Memory maintenance in synapses with calcium-based plasticity in the presence of background activity.
  Higgins D, Graupner M, Brunel N : PLoS Comput Biol, 2014
• Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine.
  Graupner M, Maex R, Gutkin B : PLoS Comput Biol, 2013
• Synaptic input correlations leading to membrane potential decorrelation of spontaneous activity in cortex.
  Graupner M, Reyes AD : J Neurosci, 2013
• Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location.
  Graupner M, Brunel N : Proc Natl Acad Sci U S A, 2012
• Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement.
  Tolu S, Eddine R, Marti F, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pagès C, Hay YA, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U : Mol Psychiatry, 2012
• Mechanisms of induction and maintenance of spike-timing dependent plasticity in biophysical synapse models.
  Graupner M, Brunel N : Front Comput Neurosci, 2010
• Computational approaches to the neurobiology of drug addiction.
  Ahmed SH, Graupner M, Gutkin B : Pharmacopsychiatry, 2009
• Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms.
  Graupner M, Gutkin B : Acta Pharmacol Sin, 2009
• STDP in a bistable synapse model based on CaMKII and associated signaling pathways.
  Graupner M, Brunel N : PLoS Comput Biol, 2007
• A theory of plasma membrane calcium pump stimulation and activity.
  Graupner M, Erler F, Meyer-Hermann M : J Biol Phys, 2005

Chapter

• Modeling Synaptic Plasticity in Hippocampus: A Calcium-Based Approach
  Graupner M, Brunel N : extracted from Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Cutsuridis V, Graham B, Cobb S, Vida I - Springer Cham, pages 615-644, ISBN:978-1-4419-0996-1, 2018