• Google Scholar: https://scholar.google.com/citations?hl=en&user=VA0yDCoAAAAJ&view_op=list_works&sortby=pubdate
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Bio

Nicolas Panayotis carried out his Ph.D. at Aix-Marseille University under the supervision of Prof. Jean-Christophe Roux (Marseille Medical Genetics Laboratory, Inserm), focusing on the MeCP2-deficient mouse model of Rett Syndrome. His work unveiled disruptions in bioaminergic and BDNFergic systems in the MeCP2 knockout mice and led preclinical developments. He then joined the laboratory of Prof. Mike Fainzilber at the Weizmann Institute of Science, Rehovot, Israel. There, he uncovered specific roles for nuclear transport factors importins in CNS and PNS functions and identified new molecular targets and pathways for the study and amelioration of MeCP2-related neurodevelopmental disorders.

Professional Experience

• SPPIN, CNRS, Université Paris Cité, Current
• Weizmann Institute of Science, Rehovot, Israel, Senior Intern, 2017-2022
• Weizmann Institute of Science, Rehovot, Israel, Post-doctoral fellow, 2012-2017
• Marseille Medical Genetics, Aix-Marseille University, Inserm, 2008-2011

Awards

• Feinberg Graduate School, Weizmann Institute of Science, FGS Prize for Outstanding Achievements in Postdoctoral Research, 2018
• Feinberg Graduate School, Weizmann Institute of Science, Koshland Senior Post Doctoral Fellowship, 2015-2017
• Jerome Lejeune Foundation Young Researcher Prize, 2011
• Ph.D. supported by the Inserm-Région Provence-Alpes-Côte d’Azur Fellowship, 2008-2011

Recent Publications

Articles

• PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.
  Alber S, Di Matteo P, Zdradzinski MD, Dalla Costa I, Medzihradszky KF, Kawaguchi R, Di Pizio A, Freund P, Panayotis N, Marvaldi L, Doron-Mandel E, Okladnikov N, Rishal I, Nevo R, Coppola G, Lee SJ, Sahoo PK, Burlingame AL, Twiss JL, Fainzilber M : Sci Adv, 2023
• State-of-the-art therapies for Rett syndrome.
  Panayotis N, Ehinger Y, Felix MS, Roux JC : Dev Med Child Neurol, 2022
• β-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice.
  Panayotis N, Freund PA, Marvaldi L, Shalit T, Brandis A, Mehlman T, Tsoory MM, Fainzilber M : Cell Rep Med, 2021
• Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
  Marvaldi L, Panayotis N, Alber S, Dagan SY, Okladnikov N, Koppel I, Di Pizio A, Song DA, Tzur Y, Terenzio M, Rishal I, Gordon D, Rother F, Hartmann E, Bader M, Fainzilber M : Science, 2020
• Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice.
  Ehinger Y, Bruyère J, Panayotis N, Abada YS, Borloz E, Matagne V, Scaramuzzino C, Vitet H, Delatour B, Saidi L, Villard L, Saudou F, Roux JC : EMBO Mol Med, 2020
• Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling.
  Panayotis N, Fainzilber M : Neuron, 2019
• Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
  Panayotis N, Sheinin A, Dagan SY, Tsoory MM, Rother F, Vadhvani M, Meshcheriakova A, Koley S, Marvaldi L, Song DA, Reuveny E, Eickholt BJ, Hartmann E, Bader M, Michaelevski I, Fainzilber M : Cell Rep, 2018
• COLORcation: A new application to phenotype exploratory behavior models of anxiety in mice.
  Dagan SY, Tsoory MM, Fainzilber M, Panayotis N : J Neurosci Methods, 2016
• Macromolecular transport in synapse to nucleus communication.
  Panayotis N, Karpova A, Kreutz MR, Fainzilber M : Trends Neurosci, 2015
• GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice.
  El-Khoury R, Panayotis N, Matagne V, Ghata A, Villard L, Roux JC : PLoS One, 2014
• Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain.
  Kaddoum L, Panayotis N, Mazarguil H, Giglia-Mari G, Roux JC, Joly E : F1000Res, 2013
• DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease.
  Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M : Brain, 2013
• [Unexpected link between Huntington disease and Rett syndrome].
  Roux JC, Zala D, Panayotis N, Borges-Correia A, Saudou F, Villard L : Med Sci (Paris), 2012
• Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway.
  Roux JC, Zala D, Panayotis N, Borges-Correia A, Saudou F, Villard L : Neurobiol Dis, 2012
• Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain.
  Panayotis N, Ghata A, Villard L, Roux JC : BMC Neurosci, 2011
• Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse.
  Panayotis N, Pratte M, Borges-Correia A, Ghata A, Villard L, Roux JC : Neurobiol Dis, 2011
• Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice.
  Pratte M, Panayotis N, Ghata A, Villard L, Roux JC : Behav Brain Res, 2011
• Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation.
  Rouaud T, Lardeux S, Panayotis N, Paleressompoulle D, Cador M, Baunez C : Proc Natl Acad Sci U S A, 2010
• Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice.
  Roux JC, Panayotis N, Dura E, Villard L : J Neurosci Res, 2010