UFR / SPPIN’s webinar winter-spring 2021, UNUSUAL TIME – 30th June at 11h30, room R229.

Niccolò Zampieri, Max-Delbrück-Centrum für Molekulare Medizin (MDC) – Berlin – Germany

Proprioception and spinal circuits for postural control

I will talk about recent work aimed at unveiling propriospinal neuron muscle identity and spinal circuits involved in postural control. We recently identified the determinants at the basis of propriospinal neuron muscle subtype identity. This discovery allowed us to selectively study proprioceptors controlling the activity of back muscles and identify molecular mechanisms controlling their identity. This work paves the way for dissecting proprioceptive circuits specifically controlling the activity of muscles with different biomechanical functions and their roles in the construction of a body map that is used for the generation of coordinated and adaptable movement.  In addition, I will discuss how an evolutionary ancient interoceptive system that is conserved among all vertebrates has surprising functions in mammalian motor control. Altogether these data highlight the importance of different spinal circuits in integrating multiple source of sensory information to precisely control movement, balance and posture.

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UFR / SPPIN’s webinar winter-spring 2021, UNUSUAL TIME – 29th June at 11h30, room R229.

Dr. Michela Di Virgilio, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany

Principles and Mechanisms of Genome Diversification & Integrity

Genomic DNA is constantly under the assault of both endogenous and exogenous damaging sources. As a result, our cells experience a multitude of DNA lesions every day. Among all the different types of DNA damage, DNA double-strand breaks (DSBs) represent one of the most dangerous lesions since they may lead to cancer-prone genome alterations. DSBs arise following exposure to ionizing radiation or radio-mimetic chemicals, but they are also generated as a by-product of normal cellular metabolism, with the majority of spontaneous DSBs originating during DNA replication. In addition to these accidental breaks, DSBs can be introduced in a programmed manner as intermediates of physiological processes such as Class Switch Recombination (CSR) in B lymphocytes, a deletional recombination reaction that changes the constant region of the antibody molecule, altering its effector function. Accurate repair of both accidental and programmed DSBs is therefore crucial to ensure both the preservation of genome integrity and the generation of genome diversity.
The research in my laboratory aims at addressing a fundamental question in Life Sciences: What are the molecular mechanisms that ensure both the integrity and diversity of our genome by modulating DSB formation and by steering their repair towards the appropriate physiological outcome? We employ mature B lymphocytes as ideal model system since in addition to experiencing programmed DNA breaks during CSR, these cells are highly proliferative and therefore susceptible to stochastic replication-associated damage, thus allowing us to comprehensively investigate the mechanisms ensuring genome diversity and stability, and their relationship.

Those interested meeting with the speaker please contact Martin Oheim.

The post 29/06 – Michela Di Virgilio : Principles and Mechanisms of Genome Diversification & Integrity first appeared on SPPIN - CNRS UMR 8003.