Team 3 – Motor Neurons & NeuroMuscular Junctions
The new team results from the fusion of 2 teams and our objective is to capitalize on the complementary expertise to investigate key pathophysiological processes that lead to motor neuron (MN) degeneration and neuromuscular disorders such as Amyotrophic Lateral Sclerosis (ALS) and Congenital Myasthenia Syndromes. Our team assembles a unique spectrum of expertise allowing us to investigate all the components of the motor units (inputs to MNs arising from spinal and supraspinal circuits, properties of motor neurons, neuromuscular junctions, and muscle fibers).
Team leaders
- Boris Lamotte d’Incamps, Research Scientist, PI, CNRS, Core unit, Team 3 - Motor Neurons & NeuroMuscular Junctionsboris.lamotte-incamps@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 43, room H333B
- Daniel Zytnicki, Senior Research Scientist, PI, CNRS, Team 3 - Motor Neurons & NeuroMuscular Junctionsdaniel.zytnicki@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 41, room H345A
Members
- Richard Amedzrovi Agbesi, Postdoctoral Researcher, Team 3 - Motor Neurons & NeuroMuscular Junctionsrichard-junior.amedzrovi-agbesi@-Code to remove to avoid SPAM-etu.u-paris.fr, +33 1 42 86 40 95, room H441
- Guillaume Caron, Assistant Professor, Université Paris Cité, Team 3 - Motor Neurons & NeuroMuscular Junctionsguillaume.caron@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09, room H343B
- Quentin Delarue, Senior Engineer, Team 3 - Motor Neurons & NeuroMuscular Junctionsquentin.delarue@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 H439, room +33 1 42 86 40 95
- Alexandre Dobbertin, Assistant Professor, Université Paris Cité, Team 3 - Motor Neurons & NeuroMuscular Junctionsalexandre.dobbertin@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 43 54, room H439
- Hafsa Er-Rouassi, Postdoctoral Researcher, Team 3 - Motor Neurons & NeuroMuscular Junctionshafsa.er-rouassi@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 43 54, room H444
- Kamil Grycz, Postdoctoral Researcher, Team 3 - Motor Neurons & NeuroMuscular Junctionskamil.grycz@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09, room H343B
- Nicolas Guérout, Professor, Université Paris Cité, Team 3 - Motor Neurons & NeuroMuscular Junctionsnicolas.guerout@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 20 68, room H439
- Ahmed Hamraoui, Assistant Professor, Team 3 - Motor Neurons & NeuroMuscular Junctionsahmed.hamraoui@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 43 54, room H444
- Anthony Harster, Assistant Engineer, Team 3 - Motor Neurons & NeuroMuscular Junctionsanthony.harster@-Code to remove to avoid SPAM-parisdescartes.fr, +33 1 76 53 42 09, room H343B
- Cédric Jan, Master Student, Team 3 - Motor Neurons & NeuroMuscular Junctionscedric.jan@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09, room H343B
- Claire Legay, Professor Emeritus, Université Paris Cité, Team 3 - Motor Neurons & NeuroMuscular Junctionsclaire.legay@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 41, room H345a
- Laurine Moncomble, PhD Student, Team 3 - Motor Neurons & NeuroMuscular Junctionslaurine.moncomble@-Code to remove to avoid SPAM-cnrs.fr, +33 1 42 86 40 95, room H441
- Pauline Neveu, PhD Student, Team 3 - Motor Neurons & NeuroMuscular Junctionspauline.neveu1@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 40 95, room H441
- Clémence Raimond, PhD Student, Team 3 - Motor Neurons & NeuroMuscular Junctionsclemence.raimond@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 40 95, room H441
- Fannie Semprez, Assistant engineer, Université Paris Cité, Team 3 - Motor Neurons & NeuroMuscular Junctionsfannie.semprez@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 40 95, room H441
- Inès Ziane, Master Student, Team 3 - Motor Neurons & NeuroMuscular Junctionsines.ziane@-Code to remove to avoid SPAM-univ-rouen.fr, +33 1 42 86 40 95, room H441
Former members
- Stefano Antonucci, PhD Student until 2023, Team 3 - Motor Neurons & NeuroMuscular Junctionsstefano.antonucci@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09
- Marcin Bączyk, Postdoctoral Researcher until 2016, Team 3 - Motor Neurons & NeuroMuscular Junctionsbaczyk@-Code to remove to avoid SPAM-awf.poznan.pl
- Marin Manuel, Research Scientist, CNRS until 2021, Team 3 - Motor Neurons & NeuroMuscular Junctionsmmanuel@-Code to remove to avoid SPAM-uri.edu, +33 1 42 86 33 56
- Rebecca Manuel, Engineer, CNRS until 2021, Team 3 - Motor Neurons & NeuroMuscular Junctionsrebecca.manuel@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 42 09
- Lourdes Martinez-Silva, Postdoctoral Researcher until 2018, Team 3 - Motor Neurons & NeuroMuscular Junctions
Recent Publications
Articles
- Mesenchymal calcium waves underpin intestinal smooth muscle differentiation
Chevalier N R, Zig L, Gomis A, Amedzrovi Agbesi R, Pontoizeau L, Eude-Le Parco I, Rouach N, Arnoux I, De Santa Barbara P, Faure S : Communications Biology, 2023 - Electrical and Mechanosensitive Activity of the Mouse Fetal Enteric Nervous System
Amedzrovi Agbesi R, Spencer N, Hebberd T, Chevalier N R : J Physiol, 2023 - Beneficial Effect of Bee Venom and Its Major Components on Facial Nerve Injury Induced in Mice.
Er-Rouassi H, Bakour M, Touzani S, Vilas-Boas M, Falcão S, Vidal C, Lyoussi B : Biomolecules, 2023 - Bumetanide increases postsynaptic inhibition after chronic SCI and decreases presynaptic inhibition with step-training.
Caron G, Bilchak J, Côté MP : J Physiol, 2023 - Flow and mixing induced by single, colinear, and colliding contractile waves in the intestine
Agbesi R J A, Chevalier N R : Physical Review Fluids, 2022 - Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
Grycz K, Głowacka A, Ji B, Krzywdzińska K, Charzyńska A, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M : Exp Neurol, 2022 - Efficacy of LED Photobiomodulation for Functional and Axonal Regeneration After Facial Nerve Section-Suture.
Er-Rouassi H, Benichou L, Lyoussi B, Vidal C : Front Neurol, 2022 - Data clustering analysis of scanning ultrafast acoustic experiments. How acoustic and structural properties of a motoneuron are revealed
Péronne E, Sénépart O, Legay C, Semprez F, Hamraoui A, Belliard L : {Physical Review Applied}, 2022 - Adhesion energy modulation acts as an NGF receptor activator for neuronal differentiation in NGF-free medium
Sénépart O, Legay C, Hélary C, Hamraoui A : Advanced Materials Interfaces, 2022 - The SELENOT mimetic PSELT promotes nerve regeneration by increasing axonal myelination in a facial nerve injury model in female rats.
Pothion H, Lihrmann I, Duclos C, Riou G, Cartier D, Boukhzar L, Lefranc B, Leprince J, Guérout N, Marie JP, Anouar Y : J Neurosci Res, 2022 - How Smooth Muscle Contractions Shape the Developing Enteric Nervous System.
Chevalier NR, Agbesi RJA, Ammouche Y, Dufour S : Front Cell Dev Biol, 2021 - Correlative Imaging of Motoneuronal Cell Elasticity by Pump and Probe Spectroscopy.
Hamraoui A, Sénépart O, Schneider M, Malaquin S, Péronne E, Becerra L, Semprez F, Legay C, Belliard L : Biophys J, 2021 - Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats.
Robac A, Neveu P, Hugede A, Garrido E, Nicol L, Delarue Q, Guérout N : Biomedicines, 2021 - RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate.
Chevreau R, Ghazale H, Ripoll C, Chalfouh C, Delarue Q, Hemonnot-Girard AL, Mamaeva D, Hirbec H, Rothhut B, Wahane S, Perrin FE, Noristani HN, Guerout N, Hugnot JP : Cells, 2021 - Plasticity of the Injured Spinal Cord.
Guérout N : Cells, 2021 - Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice.
Delarue Q, Robac A, Massardier R, Marie JP, Guérout N : J Neurosci Res, 2021 - Spinal cord injury: can we repair spinal cord non-invasively by using magnetic stimulation?
Delarue Q, Chalfouh C, Guérout N : Neural Regen Res, 2021 - Exercise-Induced Plasticity in Signaling Pathways Involved in Motor Recovery after Spinal Cord Injury.
Bilchak JN, Caron G, Côté MP : Int J Mol Sci, 2021 - Comments on the article by Jensen et al. (2020).
Manuel M, Zytnicki D : J Physiol, 2021 - Synaptic disruption and CREB-regulated transcription are restored by K channel blockers in ALS.
Catanese A, Rajkumar S, Sommer D, Freisem D, Wirth A, Aly A, Massa-López D, Olivieri A, Torelli F, Ioannidis V, Lipecka J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Mulaw MA, Roselli F, Böckers TM : EMBO Mol Med, 2021 - Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
Bączyk M, Krutki P, Zytnicki D : Physiol Rep, 2021 - Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.
Bilchak J, Yeakle K, Caron G, Malloy D, Côté MP : Exp Neurol, 2021 - L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection.
Płatek R, Grycz K, Więckowska A, Czarkowska-Bauch J, Skup M : J Neurotrauma, 2020 - AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.
Karmouch J, Delers P, Semprez F, Soyed N, Areias J, Bélanger G, Ravel-Chapuis A, Dobbertin A, Jasmin BJ, Legay C : Front Mol Neurosci, 2020 - Collagens at the vertebrate neuromuscular junction, from structure to pathologies.
Legay C, Dobbertin A : Neurosci Lett, 2020 - Building neuromuscular junctions in vitro.
Barbeau S, Tahraoui-Bories J, Legay C, Martinat C : Development, 2020 - Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ.
Barbeau S, Desprat R, Eymard B, Martinat C, Lemaitre JM, Legay C : Stem Cell Res, 2020 - Syngeneic Transplantation of Rat Olfactory Stem Cells in a Vein Conduit Improves Facial Movements and Reduces Synkinesis after Facial Nerve Injury.
Bense F, Montava M, Duclos C, Bisson A, Delarue Q, Mardion NB, Boyer O, Féron F, Guérout N, Marie JP : Plast Reconstr Surg, 2020 - The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
Karaca E, Li X, Lewicki J, Neofytou C, Guérout N, Barnabé-Heider F, Hermanson O : Mol Cell Neurosci, 2020 - Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
Delarue Q, Mayeur A, Chalfouh C, Honoré A, Duclos C, Di Giovanni M, Li X, Salaun M, Dampierre J, Vaudry D, Marie JP, Guérout N : J Neurotrauma, 2020 - The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
Chalfouh C, Guillou C, Hardouin J, Delarue Q, Li X, Duclos C, Schapman D, Marie JP, Cosette P, Guérout N : Neurotherapeutics, 2020 - A Citrus Based Sensory Functional Food Ingredient Induces Antidepressant-like Effects: Possible Involvement of an Interplay between the Olfactory and the Serotonergic Systems.
Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP : Neuroscience, 2020 - Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.
Caron G, Bilchak JN, Côté MP : J Physiol, 2020 - Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020 - Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study.
Grycz K, Głowacka A, Ji B, Czarkowska-Bauch J, Gajewska-Woźniak O, Skup M : PLoS One, 2019 - Picosecond ultrasounds as elasticity probes in neuron-like cells models
Viel A, Péronne E, Sénépart O, Becerra L, Legay C, Semprez F, Trichet L, Coradin T, Hamraoui A, Belliard L : Applied Physics Letters, 2019 - Dual innervation may occur in a partially denervated muscle.
Obongo R, Bon-Mardion N, Duclos C, Strunski V, Guerout N, Marie JP : Muscle Nerve, 2019 - pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy.
Bergua C, Chiavelli H, Allenbach Y, Arouche-Delaperche L, Arnoult C, Bourdenet G, Jean L, Zoubairi R, Guerout N, Mahler M, Benveniste O, Drouot L, Boyer O : Ann Rheum Dis, 2019 - Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
Manuel M, Zytnicki D : Current Opinion in Physiology, 2019
Chapters
- De la molécule au neurone
Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023 - De la molécule au neurone
Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023 - From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis
Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 375-394, ISBN:978-3-031-07167-6, 2022 - Diversity of Mammalian Motoneurons and Motor Units
Bączyk M, Manuel M, Roselli F, Zytnicki D : extracted from Advances in neurobiology vol. 28 Michael J O’Donovan, Mélanie Falgairolle - Springer Nature, pages 131-150, ISBN:978-3-031-07167-6, 2022
Speech communications
- Extracting Weak Signal with the Help of Data Clustering: Application to Motoneuron Adhesion
Emmanuel Péronne, Sophie Malaquin, Loic Becerra, Laurent Belliard, Ahmed Hamraoui, Claire Legay, Fannie Semprez : Forum Acusticum, Lyon, France, 2020 - Picosecond ultrasounds as elasticity probes in neuron-like cells models.
Laurent Belliard, Alexis Viel, Emmanuel Péronne, Océane Sénépart, Loic Becerra, Claire Legay, Fannie Semprez, Lea Trichet, Thibaud Coradin, Ahmed Hamraoui : Forum Acusticum, Lyon, France, 2020